MTHFR & Methylation Testing | Orchid Wellness
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Functional Genetic Testing  •  Carrollton, TX & Telehealth

MTHFR & Methylation Testing:
Understand Your Genetic Blueprint

Methylation is a process your body uses constantly to process folate, support detoxification, make neurotransmitters, and repair DNA. An MTHFR and methylation panel looks at common genetic variants in this pathway, so your nutrition and supplement plan can fit how your body works.

One-Time Test Cheek Swab or Blood Sample MTHFR C677T & A1298C Methylation Pathway Genes Telehealth Available
Book Your $250 Consultation What It Measures
About MTHFR & Methylation

Your genes don’t change.
Your plan can.

MTHFR is the gene for an enzyme that helps convert folate into its active form, methylfolate. Your body uses methylfolate in methylation, a process involved in processing homocysteine, making neurotransmitters, supporting detoxification, and repairing DNA.

Common MTHFR variants, called C677T and A1298C, are found in a large share of the population. Having a variant does not mean you have a health problem; it may mean certain processes work less efficiently. That is why Chelsea interprets your results alongside homocysteine, folate, and B12 levels, plus your symptoms and history.

At Orchid Wellness, MTHFR and methylation testing is ordered through your $250 functional consultation with Chelsea Asante, FNP-C. The test is billed separately, and because your genes do not change, it only needs to be done once.

Book Your Consultation
MTHFR
MTHFR & Methylation
Panel
Cheek swab or blood sample, depending on the panel
MTHFR C677T and A1298C variants
Related methylation pathway genes, depending on the panel
Interpreted alongside homocysteine, folate, and B12
A one-time test, since your genes do not change
Starts With Your Functional Consultation
$250
Consultation fee. The MTHFR and methylation panel is billed separately. HSA, FSA, and Cherry payment plans accepted.
What It Measures

What your methylation
genes can tell you.

An MTHFR and methylation panel looks at variants like these. Results are always paired with blood work to show how the pathway is actually working.

🧬

MTHFR C677T

The most studied MTHFR variant, which can reduce how efficiently folate is converted to its active form.
May reveal patterns like:
One copyTwo copies
🧬

MTHFR A1298C

A second common MTHFR variant, especially relevant when combined with C677T.
May reveal patterns like:
Combined variants
🔁

Methylation Pathway Genes

Depending on the panel, related genes such as MTR, MTRR, COMT, and CBS that affect B12 use, neurotransmitter breakdown, and sulfur metabolism.
May reveal patterns like:
B12 processingCOMTMethylation support
🩸

Homocysteine Context

Results are paired with a homocysteine blood level, which shows how well methylation is actually working.
May reveal patterns like:
HomocysteineFolateB12
💭

Mood Pathways

Methylation supports the production and breakdown of neurotransmitters linked to mood and focus.
May reveal patterns like:
Neurotransmitter pathways
🧪

Detoxification Support

Methylation helps your body process hormones and other compounds.
May reveal patterns like:
Estrogen metabolismDetox pathways
Who It’s For

If you want a plan built
around how you’re wired.

🩸

Elevated Homocysteine

A high homocysteine level on blood work.
🤰

Planning a Pregnancy

You are planning a pregnancy and want to talk through your folate and supplement needs.
💊

Supplement Reactions

You feel unwell on certain B vitamins or methylated supplements and want to understand why.
💭

Mood and Focus Concerns

Ongoing low mood, anxiety, or focus issues where methylation may be one piece of the picture.
👪

Family History

A family history of MTHFR variants or elevated homocysteine.
🌱

Proactive Optimization

You want a personalized supplement plan based on your genetics.
The Process

From consultation
to answers.

01
Book Your Consultation
Book your $250 functional consultation and complete your intake through your patient portal. Chelsea determines whether the MTHFR panel is right for you. The test is billed separately.
02
Receive Your Kit or Lab Order
Depending on the panel, a cheek swab kit is mailed to you or a blood draw is ordered.
03
Collect Your Sample
A cheek swab takes just a few minutes at home, or you complete a simple blood draw.
04
Live Results Review
Results typically return in about 2 to 4 weeks. Chelsea reviews your genetics with your homocysteine, folate, and B12 levels and builds your plan.
Before You Collect

How to prepare.

  • For a cheek swab, avoid eating, drinking, or brushing your teeth for at least 30 minutes before collecting, or as your kit instructs.
  • Chelsea may order homocysteine, folate, and B12 blood tests alongside your genetic test.
  • Follow the kit instructions for collection and shipping.
  • This test is done once. Your results stay the same for life.
Good to Know

Results, cost, and safety.

  • Results typically return in about 2 to 4 weeks after the lab receives your sample.
  • Functional testing is direct-pay and not typically covered by insurance. HSA and FSA cards are accepted.
  • Home kits are mailed to patients in Texas, New York, Virginia, and Washington DC.
Please note: An MTHFR variant is not a diagnosis. Genetic results describe tendencies, not certainties, and are always interpreted alongside blood work, symptoms, and history. Do not start or change high-dose supplements based on genetic results alone; Chelsea will guide you.
Explore All Functional Tests

Other testing available
at Orchid Wellness.

The MTHFR and methylation panel is one of several functional tests available through your $250 functional consultation. Learn about functional wellness

HTMA
Hair Tissue Mineral Analysis
Mineral levels and ratios, plus possible heavy metal exposure patterns, from a small hair sample.
Learn more ›
DUTCH Complete
DUTCH Complete Hormone Panel
One of the most comprehensive functional hormone tests: sex hormones, cortisol rhythm, melatonin, and metabolites.
Learn more ›
DUTCH Adrenal
DUTCH Adrenal Panel
Cortisol and DHEA across the day to show how your stress response (HPA axis) is functioning.
Learn more ›
GI-MAP
GI-MAP Stool Analysis
DNA-based gut assessment covering the microbiome, pathogens, inflammation, and digestion.
Learn more ›
IgG / IgA
Food Sensitivity Panel
Delayed food reactivity that can guide a structured elimination and reintroduction plan.
Learn more ›
OAT
Organic Acids Test
Urine-based look at energy production, neurotransmitter metabolites, B vitamins, and yeast markers.
Learn more ›
Micronutrient
Intracellular Micronutrient Panel
Vitamins, minerals, antioxidants, and amino acids measured at the cellular level.
Learn more ›
MTHFR
MTHFR and Methylation Panel
Genetic variants in your methylation pathway, interpreted alongside homocysteine, folate, and B12.
You are here
Frequently Asked Questions

MTHFR & Methylation FAQ

MTHFR stands for methylenetetrahydrofolate reductase, an enzyme that helps convert folate into its active form, methylfolate. Variants in the MTHFR gene can make this enzyme work less efficiently.
No. MTHFR variants are very common, and many people who have them never experience problems. Your results are one piece of the picture. Chelsea interprets them alongside homocysteine, folate, B12, and your symptoms before recommending any changes.
No. Your genes do not change, so MTHFR and methylation testing only needs to be done once. Follow-up blood work, such as homocysteine, may be repeated to track how your plan is working.
Yes. Your intake is completed online, many panels use a home cheek swab, and your results review can be by telehealth in Texas, New York, Virginia, and Washington DC, or in person in Carrollton.
Functional testing is generally direct-pay. HSA and FSA cards are accepted, and Cherry payment plans are available to eligible patients.
Chelsea Asante, FNP-C, functional and integrative wellness provider at Orchid Wellness Ready to Understand Your Genetics

Your genes tell a story.
Let’s read it together.

Your $250 functional consultation is your starting point. Chelsea will determine whether the MTHFR and methylation panel is right for you, and the test is billed separately. Results reviews are in person in Carrollton, Texas or by telehealth across Texas, New York, Virginia, and Washington DC.

Book your first available appointment at app.myorchidwellness.com, or call or text (469) 892-0194. Have your legal first and last name, email, and phone number ready.
Book Your $250 Consultation by state
Texas New York Virginia Washington, DC
Free Discovery Call · Extended Telehealth Hours · Cherry Payment Plans
Functional consultations and testing are direct-pay. HSA and FSA cards accepted. Payment plans are offered through Cherry and are subject to approval. Rates range from 0% to 35.99% APR based on eligibility. Cherry is not the lender.